Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia.

In this article, an attempt has been made to review the use of receptor stimulating pure agonist opioids in anesthesia, especially in patients with cardiovascular disease. Particular emphasis has been placed on the use of opioids in high...

JG Bovill，PS Sebel，TH Stanley - 《Anesthesiology》

Pharmacokinetic Interactions of Cimetidine 1987

Although cimetidine interacts with a large number of drugs, reports of incidents of drug toxicity are uncommon. This may be due to the fact that physicians are well aware of those drugs with a narrow therapeutic index which interact clin...

A Somogyi，M Muirhead - 《Clinical Pharmacokinetics》

Clinical Pharmacokinetic Considerations in the Elderly

There are numerous studies of drug handling in the elderly, but it is difficult to assess the significance of changes seen in vitro, or after single-dose a...

S Dawling，P Crome - 《Clinical Pharmacokinetics》

Opioid Analgesics in Anesthesia:With Special Reference to Their Use in Cardiovascular Anesthesia | Anesthesiology | ASA Publications

In this article, an attempt has been made to review the use of receptor stimulating pure agonist opioids in anesthesia, especially in patients with cardiov...

Lawrence J. Saidman，James G. Bovill，PETER S. SEBEL，... - PubMed

Investigations on the mode of action of a new antihypertensive drug, urapidil, in the isolated rat vas deferens

Urapidil (6-{3-[4-(o-methoxyphenyl)-1-piperazinyl]-propylamino}-1,3-dimethyluracil), phentolamine (both 10 8–10 5 M), yohimbine (10 7 M), and clonidine (1...

M Eltze - 《European Journal of Pharmacology》

Effects of urapidil, clonidine, prazosin and propranolol on autonomic nerve activity, blood pressure and heart rate in anaesthetized rats and cats

The influence of urapidil, clonidine, prazosin and propranolol on autonomic nerve activity was determined in anaesthetized cats and rats. The effects of th...

KH Sanders，I Jurna - 《European Journal of Pharmacology》

Acute haemodynamic and myocardial metabolic effects of intravenous urapidil in severe heart failure

The acute haemodynamic and myocardial metabolic effects of intravenous urapidil were evaluated in 12 patients with severe due to . Urapidil was given intra...

RY Wang，JS Chow，KH Chan，... - 《European Heart Journal》

Influence of urapidil on intracranial pressure and intracranial compliance in dogs.

During induced with , measurements of intracranial pressure and of the ventricular volume-pressure response (intracranial compliance) were obtained in with and without . A bolus of 50 mg an infusion of 8.2 +/- 1.2 mg min-1 decreased mean...

PUCHSTEIN C.，VAN AKEN H.，ANGER C.，... - 《British Journal of Anaesthesia》

Pharmacodynamics and pharmacokinetics of urapidil in hypertensive patients: A crossover study comparing infusion with an infusion-capsule combination

The pharmacokinetics and haemodynamic effects of infused urapidil and an infusion-capsule combination were followed to study the correlation between the se...

R Kirsten，K Nelson，KH Molz，... - 《European Journal of Clinical Pharmacology》

Influence of urapidil on alpha- and beta-adrenoreceptors in pithed rats.

The interaction of urapidil with pre- and postsynaptic alpha-adrenoreceptors and with postsynaptic beta-adrenoreceptors was studied in pithed normotensive rats and compared to the effects of clonidine, prazosin, and atenolol. I.v. inject...

K H. SANDERS，U. KILIAN，N. KOLASSA，... - 《Journal of Autonomic Pharmacology》