Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
摘要：
Because proinflammatory cytokines are markedly elevated during H5N1 influenza virus infection, the "cytokine storm" is hypothesized to be the main cause of mortality. Here, we demonstrate that mice deficient in the hallmark inflammatory cytokines TNF-α, IL-6, or CC chemokine ligand 2 succumb to infection with A/Vietnam/ 1203/04 (H5N1) virus, as do wild-type mice treated with glucocorticoids for suppression of cytokines. Because cytokine inhibition does not protect against death, therapies that target the virus rather than cytokines may be preferable.
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关键词：
Animals Mice, Knockout Mice Orthomyxoviridae Infections Weight Loss Cytokines Glucocorticoids Survival Rate Male Influenza A Virus, H5N1 Subtype
DOI：
10.1073/pnas.0705289104
被引量：
年份：
2007
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万方医学
掌桥科研
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