Diastereoselective synthesis of functionalized spiro[cyclopropane-1,3′-indolines] and spiro[indoline-3,1′-cyclopropane-2′,3″-indolines]
摘要：
In the presence of hexamethylphosphorous triamide, the reaction of isatin with arylidene pivaloylacetonitriles in dry methylene dichloride afforded functionalized spiro[cyclopropane-1,3′-indolines] in good yields and with high diastereoselectivity. Moreover, the similar reaction of isatins with isatylidene malononitriles predominately gave spiro[indoline-3,1′-cyclopropane-2′,3″-indolines] in very high yields with two indoline moieties intrans-configuration.
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关键词：
Diastereoselectivity Isatin Pivaloylacetonitrile Spiro[cyclopropane-1,3′-indoline Spiro[indoline-3,1′-cyclopropane-2′,3″-indoline
DOI：
10.1016/j.tet.2016.06.020
被引量：
年份：
2016
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