Differential Expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr Virus鈥揈ncoded Latent Membrane Protein-1 Identifies Distinct Histogenetic Subsets of Acquired Immunodeficiency Syndrome鈥揜elated Non-Hodgkin's Lymphomas
摘要：
This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome鈥搑elated non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS-related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and AIDS-related primary effusion lymphoma (AIDS-PEL). Forty-six cases of AIDS-NHL were investigated for the expression pattern of BCL-6, a protein specifically expressed by germinal center (GC) B-cells, and CD138/syndecan-1 (syn-1), a marker of post-GC B-cell differentiation. Expression of BCL-6 and syn-1 segregated two major phenotypic patterns among AIDS-NHL: (1) the BCL-6+/syn-1鈭pattern associated with AIDS-SNCCL and AIDS-LNCCL; (2) the BCL-6鈭syn-1+ pattern associated with AIDS-IBLP and AIDS-PEL. Among systemic AIDS-NHL infected by Epstein-Barr virus (EBV), expression of the EBV-encoded latent membrane protein-1 (LMP-1) preferentially associated with the BCL-6鈭syn-1 + profile. Analysis of nonneoplastic lymph nodes showed that the two phenotypic patterns detected in AIDS-NHL correspond to physiologic stages of B-cell development, ie, GC B-cells (BCL-6+/syn-1鈭 and preterminally differentiated post-GC B-cells (BCL-6鈭syn-1+). Thus, BCL-6+/syn-1鈭AIDS-NHL reflects a GC stage of differentiation, whereas AIDS-NHL which are BCL-6鈭syn-1+, and LMP-1+when infected by EBV, derive from B cells that have entered post-GC plasmacell differentiation. These findings are relevant for the pathogenesis and differential diagnosis of AIDS-NHL.
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年份：
1998
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