Rational design of potent antagonists to the human growth hormone receptor.

A hybrid receptor was constructed that contained the extracellular binding domain of the human growth hormone (hGH) receptor linked to the transmembrane an...

G Fuh，BC Cunningham，R Fukunaga，... - 《Science》

Signalling by Receptor Tyrosine Kinases

Annu Rev Biochem. 1993;62:453-81. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

WJ Fantl，DE Johnson，LT Williams - 《Annual Review of Biochemistry》

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate ...

DM Ornitz，A Yayon，JG Flanagan，... - 《Molecular & Cellular Biology》

Heregulin induces tyrosine phosphorylation ofHER4/p180erbB4

THE HER4/ERBB4 gene encodes a 180K transmembrane protein(HER4/pl80 erbB4 that is structurally related to the 185Kproduct (HERl/pl85 erbB2 of the HER2/ER...

GD Plowman，JM Green，JM Culouscou，... - 《Nature》

Signal transduction by allosteric receptor oligomerization

Growth factor receptors with protein tyrosine kinase activity show similar molecular anatomy and contain closely related structural elements. Hence, their ...

Schlessinger，Joseph - 《Trends in Biochemical Sciences》

Schlessinger, J. Signal transduction by allosteric receptor oligomerization. Trends Biochem. Sci. 13, 443-447

Growth factor receptors with protein tyrosine kinase activity show similar molecular anatomy and contain closely related structural elements. Hence, their ...

J Schlessinger - PubMed

The neuotrophins and their receptors.

The neurotrophins, which include nerve growth factor (NGF) and its relatives, were discovered and characterized for their distinctive ability to promote survival and differentiation of postmitotic neurons. Perhaps surprisingly, the neuro...

DJ Glass，GD Yancopoulos - 《Trends in Cell Biology》

The alphas, betas, and kinases of cytokine receptor complexes

The neurotrophins, which include nerve growth factor (NGF) and its relatives, were discovered and characterized for their distinctive ability to promote survival and differentiation of postmitotic neurons. Perhaps surprisingly, the neuro...

Neil，Stahl，and，... - 《Cell》

Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation.

Platelet-derived growth factor (PDGF) was found to induce dimerization of purified B-type PDGF receptors, as analyzed by sodium dodecyl sulfate gel electro...

CH Heldin，A Ernlund，C Rorsman，... - 《Journal of Biological Chemistry》

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

Recent studies provide evidence that defective receptors can function as a dominant negative mutation suppressing the action of wild-type receptors. This c...

O Kashles，Y Yarden，R Fischer，... - 《Molecular & Cellular Biology》