Molecular cloning of the interleukin-1 beta converting enzyme
摘要：
Interleukin-1β (IL-1β) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1β to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.
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关键词：
Animals Humans Cell Line Chromosomes, Human, Pair 11 Enzyme Precursors Metalloendopeptidases Oligodeoxyribonucleotides Poly A RNA Recombinant Proteins
DOI：
10.1126/science.1373520
被引量：
年份：
1992
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