Neutrophils in the activation and regulation of innate and adaptive immunity.

Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells. Th...

Mantovani，Alberto，Cassatella，... - 《Nature Reviews Immunology》

Neutrophils in the activation and regulation of innate and adaptive immunity.

Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular path...

Mantovani，Alberto，Cassatella，... - 《Nature Reviews Immunology》

Neutrophils in innate and adaptive immunity

Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestrati...

S Jaillon，MR Galdiero，DD Prete，... - 《Seminars in Immunopathology》

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Here, we propose a new model for understanding the Warburg effect in tumor metabolism. Our hypothesis is that epithelial cancer cells induce the Warburg ef...

 - 《Cell Cycle》

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

We and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) as a powerful single independent pred...

 - 《Cell Cycle》

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

Purpose Tumor associated macrophages (TAMs) are considered with the capacity to have both negative and positive effects on tumor growth. The prognostic va...

QW Zhang，L Liu，CY Gong，... - 《Plos One》

Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature

Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cance...

X Zhao，J Qu，Y Sun，... - 《Oncotarget》

Macrophage heterogeneity in tissues: phenotypic diversity and functions

Summary During development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the a...

S Gordon，A Plüddemann，F Martinez Estrada - 《Immunological Reviews》

Tumor microenvironment: a main actor in the metastasis process

Over recent decades, various studies have argued that the metastatic tissue microenvironment is fully controlled by the intrinsic properties of the cancer ...

SM Zollo - 《Clinical & Experimental Metastasis》

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in additio...

K Shiga，M Hara，T Nagasaki，... - 《Cancers》