Expression Of Anti-dna Immunoglobulin Transgenes In Non-autoimmune Mice

Self-reactive B cells can be regulated by either deletion or inactivation. These manifestations of self-tolerance have been dramatically shown in transgeni...

J Erikson，MZ Radic，SA Camper，... - 《Nature》

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

The transcription factor human X-box binding protein 1 (hXBP-1) is a basic region-leucine zipper protein implicated in the regulation of major histocompati...

Reimold，M A. - 《Journal of Experimental Medicine》

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

In a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was isolated with profound defects in humoral immune responses, sele...

JE Jun - 《Immunity》

Transcriptional networks in developing and mature B cells

The development of B cells from haematopoietic stem cells proceeds along a highly ordered, yet flexible, pathway. At multiple steps along this pathway, cel...

P Matthias，AG Rolink - 《Nature Reviews Immunology》

Breakdown of self-tolerance in anergic B lymphocytes

Production of autoantibodies, which characterizes most autoimmune diseases, is normally avoided by active elimination or functional inactivation (anergy) of B and T lymphocytes bearing receptors for self antigens. The mechanisms leading ...

CC Goodnow，R Brink，E Adams - 《Nature》

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors. In this report, we in...

K Venkataraman，YM Lee，J Michaud，... - 《Circulation Research》

Impaired IgA class switching in APRIL-deficient mice

The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in i...

E Castigli，S Scott，F Dedeoglu，... - 《Proc Natl Acad Sci U S A》

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor that is sufficient to trigger terminal differ,entiation in the B cell ly...

C Angelin-Duclos，G Cattoretti，KI Lin，... - 《Journal of Immunology》

Plasma Cell Survival Is Mediated by Synergistic Effects of Cytokines and Adhesion-Dependent Signals

Recent results suggest that plasma cell longevity is not an intrinsic capacity, but depends on yet unknown factors produced in their environment. In this s...

G Cassese，S Arce，AE Hauser，... - 《Journal of Immunology》

Receptor Editing in a Transgenic Mouse Model: Site, Efficiency, and Role in B Cell Tolerance and Antibody Diversification

Mice carrying transgenic rearranged V region genes in their IgH and Igkappa loci to encode an autoreactive specificity direct the emerging autoreactive progenitors into a pre-B cell compartment, in which their receptors are edited by sec...

R, Pelanda，S, Schwers，E, Sonoda，... - 《Immunity》