Expression Of Anti-dna Immunoglobulin Transgenes In Non-autoimmune Mice
摘要：
Self-reactive B cells can be regulated by either deletion or inactivation. These manifestations of self-tolerance have been dramatically shown in transgenic mice in which the number of self-reactive cells has been artificially expanded. We have now extended these models to ask if B-cell tolerance as described for non-disease-associated antigens also operates for the targets of autoimmunity. The target we have chosen is DNA. Anti-DNA antibodies are diagnostic of certain autoimmune syndromes in humans and are a characteristic of the murine model of systemic autoimmunity, the MRl/lpr mouse. Antibodies to both single-stranded and double-stranded DNA have been implicated in disease. By generating anti-DNA transgenic mice, we have addressed the question of whether DNA-specific B cells are regulated in normal (non-autoimmune) mice. We indeed found that most transgenic B cells bind DNA, yet we failed to detect secreted anti-DNA. We suggest that as a consequence of their self-reactivity these B cells are developmentally arrested.
展开
关键词：
Animals Mice B-Lymphocytes Immunoglobulin M Immunoglobulin Variable Region DNA DNA, Single-Stranded Antibodies, Monoclonal Antibodies, Antinuclear Autoantigens
DOI：
10.1038/349331a0
被引量：
年份：
1991
Nature
Nature
(全网免费下载)
EBSCO
Semantic Scholar
万方医学
查看更多
万方医学
dx.doi.org
Oxford Univ Press
Europe PMC
NCBI
NCBI
adsabs.harvard.edu
ResearchGate
(全网免费下载)
ProQuest
ResearchGate
EBSCO
EBSCO
EBSCO
readcube.com
core.ac.uk
SAGE
deepblue.lib.umich.edu
core.kmi.open.ac.uk
jem.rupress.org
hdl.handle.net
jimmunol.org
ftp.palgrave-journals.com
jacionline.org
mendeley.com
onAcademic
deepdyve.com
deepblue.lib.umich.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
