The ultrastructure of the human epidermis in chronic graft-versus-host disease.

来自 NCBI

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作者：

BB Gallucci，HM Shulman，GE Sale，KG Lerner，LE Caldwell，ED Thomas

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摘要：

The epidermal ultrastructure of 11 allogeneic bone marrow recipients with chronic graft-versus-disease (GVHD) was compared with that of 4 recipients without chronic GVHD. This microscope study revealed three patterns of epidermal injury typical of chronic GVHD. The first type was a nonacantholytic (nondissecting) injury with a prominent consisting primarily of lymphocytes accompanied by a few macrophages. The second type was an acantholytic (dissecting) injury with a prominent infiltrate, while the third was a nondissecting injury with a sparse infiltrate. Broad-zone contact was observed between lymphocytes and all epidermal types as well as between other lymphocytes and macrophages. Point contact was only observed between lymphocytes and epidermal . Lymphocytes appeared to detach from adjacent keratinocytes by isolating them with cytoplasmic projections, a phenomenon not previously described. Typical damage to the epidermal in the basal and spinous layers consisted of either swelling of the or condensation of the and . In the keratinocyte, the condensation reaction resulted in the of colloid bodies, some of which were phagocytized by macrophages. Besides the cytolytic events, a concurrent stimulatory reaction occurred in the epidermal . The number of in melanocytes and of Langerhans granules and in the Langerhans all increased. Extensive areas of replication and disruption of the were subjacent to areas of necrosis in the basal layer.

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关键词：

chronic graft versus host disease hematopoietic stem cell transplantation cyclosporine prednisone

DOI：

10.1016/j.blre.2005.01.007

被引量：

1354

年份：

1979