Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
摘要：
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
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关键词：
B-Lymphocytes Animals Mice Leukemia, Experimental Plasmacytoma Chromosome Deletion Immunoglobulins Immunoglobulin Fragments Gene Expression Regulation Recombination, Genetic
DOI：
10.1038/290372a0
被引量：
年份：
1981
Nature
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