Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer.
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摘要：
Despiteecentdvances inheanagementf non-smallell lungancer (NSCLC),he prognosisf NSCLC istillelatively poor.hus, it isf great importanceo identify novel effective diagnosticnd prognosticiomarkerf NSCLC. growing volumef literatureas demonstratedhe vitalolesf long non-codingNAs (lncRNAs) inanceriology.ancer-associatedegion long non-codingNA (CARLo-5),ecently identified lncRNA, was initiallyharacterized inolonancer.owever, little is knownbout itsole in NSCLC. Inhe presenttudy, greatpregulationfARLo-5 wasbserved inancerissuesomparedoheirdjacent normalissues.eanwhile, patients withighARLo-5 expressionaveignificantly poorer prognosishanhose with low expression. InhibitionfARLo-5yiRNAuppressedhe proliferation,igration,nd invasion in NSCLCell lines in vitro. Inddition,ilencingfARLo-5eversedhe epithelial-mesenchymalransition in NSCLCell line.urtudyuggestshatARLo-5ayepresent prognosticarkernd potentialherapeuticargetf NSCLC.
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年份：
2014
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