Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

Szeto，H.，H.，... - 《Clinical Pharmacology & Therapeutics St Louis》

In vivo occupancy of dopamine D2 receptors by antipsychotic drugs and novel compounds in the mouse striatum and olfactory tubercles

Interaction with dopamine D 2 -like receptors plays a major role in the therapeutic effects of antipsychotic drugs. We examined in vivo dopamine D 2 recep...

MB Assié，H Dominguez，N Consul-Denjean，... - Naunyn-Schmiedeberg's Archives of Pharmacology

Compositions and methods relating to novel compounds and targets thereof

The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzod...

GD Glick - US

Psoracorylifols A–E, five novel compounds with activity against Helicobacter pylori from seeds of Psoralea corylifolia

Five novel compounds, psoracorylifols A–E ( 1– 5) with important activity against Helicobacter pylori have been isolated from a well-known traditional Ch...

Y Sheng，C Fan，D Lei，... - 《Tetrahedron》

Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

Background The cyclin-dependent kinase (CDK) inhibitor p27Kip1 is downregulated in a majority of human cancers due to ectopic proteolysis by the ubiquitin-...

L Lu，CC Yang，RB Elizabeth，... - 《Bmc Biology》

Novel compounds and therapeutic uses thereof

The invention discloses a novel series of compound represented by general formula (I), 1 its derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, solvates wherein X, n, k, z, R1, R2, R3, ...

A Sankaranarayanan - US

Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor

There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or...

A Fisher，N Bar-Ner，Y Karton - US

Formation and magnetic properties of novel compounds Tb3(Fe1xVx)29

A systematic investigation of the structure and magnetic properties of novel compoundsTb3(Fe1xVx)29(x=0.033, 0.044, 0.056, and 0.061) has been performed. T...

XF Han，FM Yang，JJ Zhu，... - 《Journal of Applied Physics》

Anti-inflammatory activity of 21(alpha, beta)-methylmelianodiols, novel compounds from Poncirus trifoliata Rafinesque

The fruits of Poncirus trifoliata (L.) are widely used in Oriental medicine as a remedy for allergic inflammation. As a part of our program to screen medic...

YZ Hong，EM Shin，YG Lian，... - 《European Journal of Pharmacology》

Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

Background聽聽The cyclin-dependent kinase (CDK) inhibitor p27^Kip1 is downregulated in a majority of human cancers due to ectopic proteolysis by ...

Elizabeth，Rico-Bautista，Chih-Cheng，... - 《Bmc Biology》