Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A r...

MD Waterfield，GT Scrace，N Whittle，... - 《Nature》

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide ROLE IN EGF RECEPTOR-MEDIATED TYROSINE PHOSPHORYLATION

Recent evidence indicates that reactive oxygen species (ROS) may function as intracellular messengers in receptor signaling pathways. The possible role of ...

Kang，W S. - 《Journal of Biological Chemistry》

Biological robustness

Robustness is a ubiquitously observed property of biological systems. It is considered to be a fundamental feature of complex evolvable systems. It is atta...

H Kitano - Sice Conference

Biological Robustness - A Principle in Systems Biology

Robustness is a ubiquitously observed property of biological systems. It is considered to be a fundamental feature of complex evolvable systems. It is atta...

H Kitano - 《Nature Reviews Genetics》

Platelet-derived growth factor is structurally related to the putative transforming protein p28^sis of simian sarcoma virus

A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A r...

M Warfd，O Scrac，N Wh，... - 《Nature》

IRS proteins and the common path to diabetes

Although a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the discovery of insulin receptor substrate (IRS) proteins an...

White，Morris F. - 《Ajp Endocrinology & Metabolism》

The Catalogue of Somatic Mutations in Cancer (COSMIC)

COSMIC is currently the most comprehensive global resource for information on somatic mutations in human cancer, combining curation of the scientific liter...

SA Forbes，G Bhamra，S Bamford，... - 《Curr Protoc Hum Genet》

Cell-signalling dynamics in time and space.

Nat Rev Mol Cell Biol. 2006 Mar;7(3):165-76. Research Support, N.I.H., Extramural; Review

Kholodenko，N Boris - 《Nature Reviews Molecular Cell Biology》

Robustness of cellular functions.

Robustness, the ability to maintain performance in the face of perturbations and uncertainty, is a long-recognized key property of living systems. Owing to...

J Stelling，U Sauer，Z Szallasi，... - 《Cell》

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.

We report the crystal structure, at 2.5 Å resolution, of a truncated human EGFR ectodomain bound to TGFα. TGFα interacts with both L1 and L2 domains o...

TPJ Garrett，NM Mckern，M Lou，... - 《Cell》