Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
摘要：
A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28 sis , the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.
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关键词：
Animals Humans Retroviridae Sarcoma Virus, Woolly Monkey Cell Transformation, Neoplastic Macromolecular Substances Growth Substances Platelet-Derived Growth Factor Peptides Oncogene Proteins v-sis
DOI：
10.1038/304035a0
被引量：
年份：
1983
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