Germinal centers develop in peripheral lymphatic tissue during the primary immune response and may play a crucial role in affinity maturation. We have comp...
Studies on the development of the immune response suggest that the repertoire of expressed antibody specificities is strongly influenced by antigen (review...
This chapter focuses on the maturation of the immune response. The maturation of the immune system is considered to be a precisely controlled process, whic...
importantly, development of a repertoire of memory cells by d20, may define immune response capabilities that close the period of immaturity for the ...
During B-cell development from the hematopoietic stem cell a primary repertoire of roughly 1010 different B-cell receptors can be generated from just a few...
69 germline gene is represented at a high frequency in the human antibody repertoire and is seen in the early immune response to a variety of pathogens...
Antibody and T-cell receptor (TCR) molecules may be regarded as products of a protein engineering system for the generation of a virtually unlimited repertoire of complementary molecular surfaces. This extreme structural heterogeneity is...
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a...
The paratypic and idiotypic diversity of the BALB/c antibody response to the hemagglutinin (HA) of the influenza A/PR/8/34 virus (PR8) was investigated using a panel of 125 anti-HA hybridoma antibodies derived from 14 BALB/c mice. The pa...
The most J H -proximal V H gene segments are used highly preferentially to form V H DJ H rearrangements in pre-B-cell lines. This result demonstrates tha...
The variable regions of immunoglobulin heavy chains are encoded in the germ line by three discrete DNA segments: V(variable) elements, D (diversity) elements and J(joining) elements. During the differentiation of B lymphocytes, individua...
We have examined the amino-terminal sequence of the κ light chains of a set of monoclonal antibodies specific for one of the major antigenic determinants ...
Studies on the development of the immune response suggest that the repertoire of expressed antibody specificities is strongly influenced by antigen (review...
Sequence analysis of the heavy- and light-chain messenger RNA of hybridomas immunized with a specific hapten yields important clues about the interplay bet...
We have analyzed the structure of the interface between VL and VH domains in three immunoglobulin fragments: Fab KOL, Fab NEW and Fab MCPC 603. About 1800 ...
This paper deals with code acquisition in communication systems with large frequency offsets. In such a situation, the receiver has to perform a 2-dimensio...
