Tonegawa, S. Somatic generation of antibody diversity. Nature 302, 575
摘要：
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
展开
关键词：
Animals Humans DNA Transposable Elements Antibodies Base Sequence Mutation Immunoglobulins Base Composition Genes
DOI：
10.1038/302575a0
被引量：
年份：
1983
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
