A short amino acid sequence able to specify nuclear location.

A short sequence of amino acids including Lys-128 is required for the normal nuclear accumulation of wild-type and deleted forms of SV40 large T antigen. A...

D Kalderon，BL Roberts，WD Richardson，... - 《Cell》

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B.

Nuclear factor kappa B (NF-kappa B), which was first detected by its binding to the kappa B site in the immunoglobulin kappa-gene enhancer, is important fo...

GHOSH,S. - 《Nature》

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

We have detected nuclear localization signals within the 795 amino acid rat glucocorticoid receptor. Using a transient expression assay, we monitored by immunofluorescence the subcellular distribution of receptor derivatives and beta-gal...

D Picard，KR Yamamoto - 《Embo Journal》

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including...

F Shirakawa，SB Mizel - 《Molecular & Cellular Biology》

Nuclear envelope permeability

The permeability of the amphibian oocyte nuclear envelope in situ has been determined for three tritiated dextrans. The envelope is a sieve, restricting mo...

PL Paine，LC Moore，SB Horowitz - 《Nature》

Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores.

When injected into the cytoplasm of Vero cells, nucleoplasmin rapidly concentrates in a narrow layer around the nuclear envelope and then accumulates within the nucleus. Transport into the nucleus can be reversibly arrested at the perinu...

WD Richardson，AD Mills，SM Dilworth，... - 《Cell》

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

Using monoclonal antibodies we identified a group of eight polypeptides of rat liver nuclear envelopes that have common epitopes. Most or all of these proteins are structurally distinct, as shown by tryptic peptide mapping and analysis w...

CM Snow，A Senior，L Gerace - 《Journal of Cell Biology》

Nuclear envelope permeability. Nature 254: 109-114

The permeability of the amphibian oocyte nuclear envelope in situ has been determined for three tritiated dextrans. The envelope is a sieve, restricting mo...

PL Paine，LC Moore，SB Horowitz - 《Nature》

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. ...

JA Glomset，MH Gelb，CC Farnsworth - 《Trends in Biochemical Sciences》

Nuclear envelope permeability.

Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. ...

TL Moore，BS Horowitz，ML Paine