The molecular logic of endocannabinoid signalling

Nat Rev Neurosci. 2003 Nov;4(11):873-84. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

D Piomelli - 《Nature Reviews Neuroscience》

Modulation of anxiety through blockade of anandamide hydrolysis.

The psychoactive constituent of cannabis, Delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, ind...

S Kathuria，S Gaetani，D Fegley，... - 《Nature Medicine》

Role of Endogenous Cannabinoids in Synaptic Signaling.

Research of cannabinoid actions was boosted in the 1990s by remarkable discoveries including identification of endogenous compounds with cannabimimetic act...

Freund，F Tamas，Katona，... - 《Physiological Reviews》

MODULATION OF ANXIETY THROUGH BLOCKADE OF ANANDAMIDE HYDROLYSIS

Fatty acid amide hydrolase inhibitors of the Formula: are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selecte...

PIOMELLI Daniele，DURANTI Andrea，TONTINI Andrea，... - CN

Wilson RI, Nicoll RA. Endocannabinoid signaling in the brain. Science 296: 678-682

The primary psychoactive ingredient in cannabis, 螖9-tetrahydrocannabinol (螖9-THC), affects the brain mainly by activating a specific receptor (CB1). CB1 ...

RI Wilson，RA Nicoll - 《Science》

Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension

Background— Endocannabinoids are novel lipid mediators with hypotensive and cardiodepressor activity. Here, we examined the possible role of the endocanna...

Batkai，S. - 《Circulation》

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is termina...

JZ Long，W Li，L Booker，... - 《Nature Chemical Biology》

Cannabinoid receptors and their ligands

There are at least two types of cannabinoid receptors, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors exist primarily on central and peripher...

RG Pertwee，RA Ross - 《Prostaglandins Leukot Essent Fatty Acids》

Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility.

Focal cerebral ischemia (FCI) induces rapid neuronal death in the ischemic core, which gradually expands toward the penumbra, partly as the result of a neu...

A Franklin，S Parmentierbatteur，L Walter，... - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》

Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling

Cellular communication in the nervous system is mediated by chemical messengers that include amino acids, monoamines, peptide hormones, and lipids. An inte...

Bracey，H M. - 《Science》