The role of signaling pathways in the development and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a multifaceted molecular pathogenesis. Current evidence indicates...

S Whittaker，R Marais，AX Zhu - 《Oncogene》

Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer

Advanced prostate tumors, which are androgen dependent, are often initially treated in the clinic with hormone ablation therapy, either through surgical ca...

KR Lamont，DJ Tindall - 《Molecular Endocrinology》

Direct Ubiquitination of Pattern Recognition Receptor FLS2 Attenuates Plant Innate Immunity

Innate immune responses are triggered by the activation of pattern-recognition receptors (PRRs). The Arabidopsis PRR FLAGELLIN-SENSING 2 (FLS2) senses bact...

D Lu，W Lin，X Gao，... - 《Science》

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

DLL4–Notch signalling suppresses endothelial sprouting and angiogenic growth through crosstalk with the vascular endothelial growth factor (VEGF) pathway;...

B Rui，SF Rocha，M Woeste，... - 《Nature》

Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.

Noonan, LEOPARD, and cardiofaciocutaneous syndromes (NS, LS, and CFCS) are developmental disorders with overlapping features including distinctive facial d...

A Sarkozy，C Carta，S Moretti，... - 《Human Mutation》

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

MicroRNAs (miRNAs) are generated by two-step processing to yield small RNAs that negatively regulate target gene expression at the post-transcriptional lev...

 - 《Nature》

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.

The oncogenic receptor tyrosine kinase EGFR regulates the core autophagy machinery by phosphorylating the autophagy protein Beclin 1. This regulation may c...

Y Wei，Z Zou，N Becker，... - 《Cell》

Sunitinib Acts Primarily on Tumor Endothelium rather than Tumor Cells to Inhibit the Growth of Renal Cell Carcinoma

Sunitinib is a broad-spectrum small-molecule inhibitor of receptor tyrosine kinases (RTK) that serves as the present standard of care for first-line therap...

D Huang，Y Ding，Y Li，... - 《Cancer Research》

Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Activation of the epidermal growth factor receptor (EGFR) in glioblastoma (GBM) occurs through mutations or deletions in the extracellular (EC) domain. Unl...

 - 《Cancer Discovery》

A Plasma Membrane Receptor Kinase, GHR1, Mediates Abscisic Acid- and Hydrogen Peroxide-Regulated Stomatal Movement in Arabidopsis

The plant hormone abscisic acid (ABA) regulates stomatal movement under drought stress, and this regulation requires hydrogen peroxide (H 2 O 2 ). We isola...

D Hua，C Wang，J He，... - 《Plant Cell》