Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.

The role of eosinophils as effector cells in asthma pathogenesis has been questioned since an anti-interleukin (IL)-5 monoclonal antibody (mepolizumab), wh...

PT Flood-Page，AN Menzies-Gow，AB Kay，... - 《Am J Respir Crit Care Med》

Mepolizumab and exacerbations of refractory eosinophilic asthma.

The article reports on research which attempted to determine if eosinophilic inflammation of the airway is associated with the risk of exacerbations of ast...

P Haldar，CE Brightling，B Hargadon，... - 《New England Journal of Medicine》

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia.

The article reports on the results of research which was conducted to determine the effect mepolizumab had on patients with prednisone dependent asthma wit...

P Nair，MMM Pizzichini，M Kjarsgaard，... - 《New England Journal of Medicine》

Mepolizumab and exacerbations of refractory eosinophilic asthma.

Exacerbations of asthma are associated with substantial morbidity and mortality and with considerable use of health care resources. Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflam...

P Haldar，B Hargadon，S Gupat

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

Recombinant human interleukin-5 (rhIL-5), in either liquid or semi-solid cultures, selectively induced eosinophil production from normal human bone marrow, with no activity on other cell lineages. The time course of eosinophil production...

EJ Clutterbuck，CJ Sanderson - 《Blood》

Lebrikizumab Treatment in Adults with Asthma

Recombinant human interleukin-5 (rhIL-5), in either liquid or semi-solid cultures, selectively induced eosinophil production from normal human bone marrow, with no activity on other cell lineages. The time course of eosinophil production...

ED Bateman

Lebrikizumab treatment in adults with asthma

Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicin...

MD Eisner

Lebrikizumab Treatment in Adults with Asthma

Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicin...

W Surs

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

Background: The debate as to whether asthma is a single or heterogeneous disease remains unresolved although pathological studies, mostly using fibreoptic ...

Green，R H - 《Thorax》

The global burden of asthma.

There has been a sharp increase in the global prevalence, morbidity, mortality, and economic burden associated with asthma over the last 40 years, particul...

Braman，S Sidney - 《Chest》