Proliferative action of leukaemia inhibitory factor on satellite cells
申请(专利)号：
CA 2045630
申请日期：
Nov 20, 1990
公开/公告号：
CA 2045630 A1
申请(专利权)人：
国省代号：
WO
被引量：
摘要：
(57) Abstract The present invention relates to the use of leukaemia inhibitory factor (LiF), alone or in combination witj other cytokines such as interleukin-6 (IL-6) and/or transforming growth factor .alpha.(FGF.alpha.) and/or fibroblast growth factor (FGF), to stimulate the ?liferation and/or differentiation of mammalian satellite cells. THe present invention also contemplates a method comprising ?yoblast transfer therapy whereby LIF, alone or in combination with other cytokines, is/are employed to proliferate and/or dif-ferentiate mammalian satellite cells into myoblasts. The present invention is also directed to a cell activating composition and a pharmaceutical composition comprising LIF alone or in combination with other cytokines to promote proliferation and/or differ-entiation of mammalian satellite cells in vitro and in vivo, respectively.
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