Diastereoselective Hydroxyalkylation of the 1Position of 2-Pivaloyl 1,2,3,4-tetrahydroisoquinoline via Magnesium Derivatives
摘要：
The first diastereoselective synthesis of the hydroxyamides 2 has been achieved using the magnesium reagent 1 and aldehydes. Acid-catalyzed rearrangement of 2, R = Ph, leads, depending on the conditions, cleanly to l- or u-amino esters 3. These results are interesting, inter alia, in connection with the synthesis of isoquinoline alkaloids with -hydroxylated side chains in the 1-position.
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DOI：
10.1002/anie.198402481
被引量：
年份：
1984
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2010
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