Kinase inhibitors and methods of their use
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and comp...
Burger, Matthew，Lindvall, Mika，W Han，... - US
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R 1 , and R 2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmac...
CHARRIER, Jean-Damien，YOUNG, Stephen, Clinton，DAVIS, Christopher, John，... - EP
Pim激酶抑制剂及其制备方法与在制药中的应用
本发明提供了一种式(I)所示的PIM激酶抑制剂,其中E,J,Q,X,Y,Z,m如权利要求1所定义.本发明的PIM激酶抑制剂用于制备治疗或预防癌症,自身免疫性疾病,过敏性反应疾病,动脉...
Yu Ge，葛羽
Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is a thiazolyl, picolinyl, pyridinyl, or pyrimidinyl, are usefu...
X Wang - US
PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts ...
X Wang
Kinase inhibitors and methods of their use
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts ...
- US
Antiproliferative Compounds
Tin Complexes, Antitumor Activity
BK Albrecht，SF Bellon，VS Gehling，... - Springer New York
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activit...
T Huang，CB Xue - WO
Sirtuin modulating compounds
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorder...
J Bemis，JS Disch，PY Ng，... - US
OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS
The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in pharmaceutically acceptable salt form, to their preparation, to their medical...
HURTH Konstanze，LUEOEND Rainer Martin，MACHAUER Rainer，...
