Nutritional supplements and therapeutic compositions comprising (r)-3- hydroxybutyrate derivatives

阅读量:

11

申请(专利)号:

CA20042527940

申请日期:

2004-06-03

公开/公告号:

CA2527940A1

公开/公告日期:

2004-12-16

申请(专利权)人:

THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC RETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;ISIS INNOVATION, THE TECHNOLOGY TRANSFER COMPANY FOR THE UNIVERSITY OF O XFORD

发明人:

RL VeechMT King

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被引量:

49

摘要:

Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catlyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.

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