Reconsidering GHB: orphan drug or new model antidepressant?
摘要：
For six decades, the principal mode of action of antidepressant drugs is the inhibition of monoamine re-uptake from the synaptic cleft. Tricyclic antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and the new generation of dual antidepressants all exert their antidepressant effects by this mechanism. In the early days of the monoaminergic era, other efforts have been made to ameliorate the symptoms of depression by pharmacological means. The gamma-aminobutyric acid (GABA) system was and possibly still is one of the main alternative drug targets. Gammahydroxybutyrate (GHB) was developed as an orally active GABA analogue. It was tested in animal models of depression and human studies. The effects on sleep, agitation, anhedonia and depression were promising. However, the rise of benzodiazepines and tricyclic antidepressants brought GHB out of the scope of possible treatment alternatives. GHB is a GABA(B) and GHB receptor agonist with a unique spectrum of behavioural, neuroendocrine and sleep effects, and improves daytime sleepiness in various disorders such as narcolepsy, Parkinson's disease and fibromyalgia. Although it was banned from the US market at the end of the 1990s because of its abuse and overdose potential, it later was approved for the treatment of narcolepsy. New research methods and an extended view on other neurotransmitter systems as possible treatment targets of antidepressant treatment brought GHB back to the scene. This article discusses the unique neurobiological effects of GHB, its misuse potential and possible role as a model substance for the development of novel pharmacological treatment strategies in depressive disorders.
展开
关键词：
Gammahydroxybutyrate GHB sodium oxybate depression residual symptoms antidepressant slow wave sleep narcolepsy gamma-amniobutyric acid GABA
DOI：
10.1177/0269881111421975
被引量：
年份：
2011
国家科技图书文献中心
(权威机构)
EBSCO
Semantic Scholar
掌桥科研
万方医学
查看更多
dx.doi.org
NCBI
NCBI
Oxford Univ Press
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
core.ac.uk
(全网免费下载)
zora.uzh.ch
(全网免费下载)
deepdyve.com
zora.uzh.ch
safetylit.org
onacademic.com
学术范
(全网免费下载)
mendeley.com
frontiersin.org
jop.sagepub.com
pubfacts.com
www.socolar.com
mysciencework.com
学术范
growkudos.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
