Nucleic acid hybridization assay and detectable molecules useful in such assay
A detectable molecule of the formula A 3 --(--X--R 1 --E--Det b ) m where A 3 is A 2 or a polymer, where A 3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imi...
JG Stavrianopoulos - US
4795700 Nucleic acid probes and methods of using same: Peter B Dervan, Geoffrey B Dreyer assigned to California Institute of Technology
A detectable molecule of the formula A 3 --(--X--R 1 --E--Det b ) m where A 3 is A 2 or a polymer, where A 3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imi...
None - 《Biotechnology Advances》
Biopolymer linked to a chelating agent based on an o-cyclohexadiaminediacetic acid
where A 3 is A 2 or a polymer, where A 3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halide...
JG Stavrianopoulos - US
Nucleic acid probes and methods of using same
A probe and method for specific recognition or cleavage of single- stranded DNA or RNA at desired loci utilizing sequence-specific polynucleotide-chelator probes. The probe may also be utilized as a diagnostic agent when the metal ion is...
PB Dervan，GB Dreyer - US
Non-radioactive nucleic acid hybridization probes
The adduct is useful in constructing non-radioactive nucleic acid hydridization probes.
Al-hakim, Ali H.，R Hull - EP
LANTHANIDE CHELATE-TAGGED NUCLEIC ACID PROBES
Nucleic acid probes are provided which are chemically tagged with moieties which chelate the trivalent lanthanides Eu?+3, Tb+3 and Sm+3. Also provided are methods of making said probes and methods of using the probes in hybridization ass...
GARY FRED MUSSO，SOUMITRA SHANKAR GHOSH，THOMAS RAYMOND GINGERAS - EP
Immunological reagents employing polymeric backbones
Nucleic acid probes are provided which are chemically tagged with moieties which chelate the trivalent lanthanides Eu?+3, Tb+3 and Sm+3. Also provided are methods of making said probes and methods of using the probes in hybridization ass...
Fluorescent labels comprising rare earth chelates
There are described stabilized fluorescent labels comprising rare earth chelate incorporated in polymeric beads derived from a latex. Labeled reactive proteinaceous species such as labeled immunoreagents comprising the stabilized fluores...
DS Frank，MW Sundberg - US
PHOTOCHEMICAL METHOD OF LABELLING NUCLEIC ACIDS
In a test for the presence of a particular nucleic acid in a test sample wherein the same is subjected to hybridizing conditions with a lbeled nucleic acid probe, and the product is assayed for the presence of said label, the improvement...
NANIBHUSHAN DATTAGUPTA - EP
Fluorescent labels comprising rare earth chelates
There are described stabilized fluorescent labels comprising rare earth chelate incorporated in polymeric beads derived from a latex. Labeled reactive proteinaceous species such as labeled immunoreagents comprising the stabilized fluores...
DS Frank，MW Sundberg - US
