Matrices of a polylactam copolymer of glutamic acid and monoethyl glutamate; controlled and sustained release
公开/公告号：
US4450150 A
公开/公告日期：
May 22, 1984
被引量：
摘要：
An implantable drug deliver depot comprising a hydrophilic poly(glutamic acid-co-ethyl glutamate) structure having one or more substances, e.g., drugs and/or diagnostic agents physically contained therein. The drug or diagnostic agent is released by its permeation of and diffusion through the copolymer structure. The depot may be designed to release the substance or substances at predetermined rates and in predetermined sequence. The copolymer structure ultimately biodegrades to glutamic acid. Among the preferred configurations for the depots are rods and closed-end capsules.
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