摘要：

A compound, or a pharmaceutically acceptable salt thereof, represented by formula IIa: ** (See formula) ** in which "*" indicates a carbon in which the sulfamoyl group may be attached X4 is -NR4- or - OR-; m is 0, 1 or 2; R1 can replace a hydrogen atom of any CH bond in the indole ring and, for each occurrence, is independently deutero, hydroxy, nitro, halo, cyano, carboxy, formyl, C1-7 alkyl, C3-8 carbocyclyl, C2 alkenyl -7, C2-7 alkynyl, C1-7 alkoxy, C1-7 alkylthio, C3-8 cycloalkoxy, C6-10 aryl, C6-10 arylC1-4 C6-10-aryloxy alkyl, amino, N- C1-7 alkylamino, N, N-di- (C1-7 alkyl) amino, N-C6-10 arylamino, 3-10 membered heterocyclyl, N- (3-10 membered heterocyclyl) amino, (3-10 membered heterocyclyl) oxy, 5-10 membered heteroaryl, (5-10 membered heteroaryl) C1-4 alkyl, N-heteroaryl (5-10 membered amino), 5-10 membered heteroaryloxy, C1-7 alkanoyl, C1-7 alkoxycarbonyl, alkanoyloxy C1-7, C1-7 alkylamido, C6-10 arylamido, (3-10 membered heterocyclyl) amido, carbamoyl, N- C1-7 alkyl carbamoyl, N, N-di- (C1-7 alkyl) carbamoyl, C1 alkoxy -7 amido, C1-7 alkyl ureido and C6-10 aryl ureido, in which R1 is optionally substituted in one or more carbon atoms with one or more independently selected R13; and wherein when R1 comprises a heterocyclyl or a heteroaryl comprising one or more - NH-, the hydrogen of each group -NH- can be optionally independently substituted with R22; or two R1 on the same carbon atom together can form an oxo; or two R1 in the same carbon atom together with the carbon to which they are attached form a C3-8 carbocyclyl spiro; or two R1 in adjacent carbon atoms together with the carbon atoms to which they are attached can form a C3-8 condensed carbocyclyl or phenyl which may be optionally substituted with one or more R13; and R3 is selected from the group consisting of a C1-7 alkyl, a C3-8carbocyclyl, a C3-8carbocyclyl C1-4alkyl, a C6-10 aryl, a C6-10arylC1-4alkyl, a 5-10 membered heteroaryl, a (5 to 10 members heteroaryl) C1-4 alkyl, a 3 to 10 member heterocyclyl and a (3 to 10 member heterocyclyl) C1-4 alkyl, wherein R3 is optionally substituted at one or more carbon atoms with one or more R14; and wherein when R3 comprises a heteroaryl or heterocyclyl comprising one or more -NH-, the hydrogen of each group -NH- can be optionally independently substituted with a C1-7 alkyl; R4 is hydrogen, C1-7 alkyl or C1-4 alkoxy C1-4 alkyl; or R3 and R4, together with the nitrogen atom to which they are attached, form a 3- to 7-membered heterocyclyl, where the heterocyclyl can be optionally substituted at one or more carbon atoms with one or more R15; and wherein when the heterocyclyl comprises one or more -NH-, the hydrogen of each group -NH- can be optionally independently substituted with R16; R13, for each occurrence, is independently deutero, nitro, halo, cyano, hydroxy, carboxy, C1-7 alkyl, C3-8 cycloalkyl, C1-7 alkoxy, C6-10 aryl, C6-10 aryloxy, heterocyclyl from 3 to 10 members, 5-10 membered heteroaryl, amino, C1-7 alkylamino, di- (C1-7 alkyl) amino, C1-7 alkanoyl, C1-7 alkoxycarbonyl, C1-7 alkanoyloxy, C1-7 alkylamino, C1-7 alkoxyamido , carbamoyl, N-C 1-7 alkyl carbamoyl, N, N-di- (C 1-7 alkyl) carbamoyl, C 1-7 alkylsulfonyl, C 1-7 alkylsulfonyloxy, C 1-7 alkylsulfonamido, sulfamoyl, N- C 1-7 alkylsulfamoyl, or N, N-di- (C1-7 alkyl) sulfamoyl, where R13 is optionally substituted at one or more carbon atoms with one or more independently selected R17; and wherein when R13 is a heterocyclyl or a heteroaryl comprising one or more -NH-, the hydrogen of each group -NH- can be independently optionally substituted with R20; or two R13 on the same carbon atom together can form an oxo or a C3-8carbocyclyl spiro; or two R13 in adjacent carbon atoms together with the carbons to which they are attached can form a 3- to 7-membered heterocyclyl which may be optionally substituted at one or more carbon atoms with one or more R17 and if the heterocyclyl comprises one or more groups -NH-, the hydrogen of each group -NH- can be optionally independently substituted with R20; ...

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