Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3- carboxylic acids

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline- 3- carboxylic acids and the pharmaceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4- tetrahydroisoquinoline with a suitably substit...

ML Hoefle，S Klutchko - US

ChemInform Abstract: The Dakin—West Reaction of N‐Acyl‐1,2,3,4‐tetrahydroisoquinoline‐1‐carboxylic Acids Using Trifluoroacetic Anhydride: Structural ...

ChemInform Abstract: The Dakin—West Reaction of N‐Acyl‐1,2,3,4‐tetrahydroisoquinoline‐1‐carboxylic Acids Using Trifluoroacetic Anhydride: Structural ...

M Kawase，Y Okada，H Miyamae - 《Cheminform》

2-Acyl-tetrahydroisoquinoline-3-carboxylic acids: lead compounds with triple actions, peroxisome proliferator-activated receptor α/γ agonist and protein-...

Acyl-tetrahydroisoquinoline-3-carboxylic acids: lead compounds with triple actions, peroxisome proliferator-activated receptor α/γ agonist and protein-tyrosine ...

K Otake，S Azukizawa，K Takahashi，... - 《Chemical & Pharmaceutical Bulletin》

Acylderivat of the substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Acyl-tetrahydroisoquinoline-3-carboxylic acids: lead compounds with triple actions, peroxisome proliferator-activated receptor α/γ agonist and protein-tyrosine ...

M Hoefle，S Klutchko

N-Acyl 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline: The First Orexin-2 Receptor Selective Non-Peptide Antagonist.

For Abstract see ChemInform Abstract in Full Text.

M Hirose，SI Egashira，Y Goto，... - 《Cheminform》

Design, synthesis, and inhibition of platelet aggregation for some 1-o-chlorophenyl-1,2,3,4-tetrahydroisoquinoline derivatives

Based on ticlopidine active as an ADP receptor antagonist for inhibiting platelet aggregation in clinical test, and upon finding (卤)-1,2-substituted-7-sul...

J Yang，WY Hua，FX Wang，... - 《Bioorganic & Medicinal Chemistry》

Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies.

Recent work in our laboratory has shown that the highly substituted, electronically rich 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQ3CA) scaffol...

RA Al-Horani，UR Desai - 《Tetrahedron》

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same

The substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and the pharmaceutically acceptable salts thereof may be produced by coupling a suitably substituted 1,2,3,4-tetrahydroisoquinoline with a suitably sub...

ML Hoefle，S Klutchko - EP

N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

N-substituted amino acids are described which when coupled with 1,2,3, 4-tetrahydroisoquinolines result in substituted acyl derivatives of 1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acids as anti- hypertensive agents. The novel interme...

ML Hoefle，S Klutchko - US