Method for reduction of migraine headache pain

The invention is a method for reducing headache pain and symptoms associated with the onset or occurrence of headache in mammals. The method is performed by delivering an invertebrate presynaptic neurotoxin to a mammal extramuscularly (...

WJ Binder - US

Intracellular Messengers Contributing to Persistent Nociception and Hyperalgesia Induced by L〨lutamate and Substance P in the Rat Formalin Pain Model

The contribution of the intracellular messengers nitric oxide, arachidonic acid and protein kinase C to persistent nociception in response to tissue injury...

TJ Coderre，K Yashpal - 《European Journal of Neuroscience》

Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain.

Substance P (SP) plays a central role in the transduction of second messenger signals from primary afferent nociceptive terminals to second-order neurons i...

R Benoliel，E Eliav，AJ Mannes，... - 《Pain》

Immunotoxin conjugates employing toxin B chain moieties

Substance P (SP) plays a central role in the transduction of second messenger signals from primary afferent nociceptive terminals to second-order neurons i...

JW Uhr，ES Vitetta

Clostridial toxin derivatives able to modify peripheral sensory afferent functions

The invention relates to an agent specific for peripheral sensory afferents. The agent may inhibit the transmission of signals between a primary sensory afferent and a projection neutron by controlling the release of at least one neurotr...

KA Foster，MJ Duggan，CC Shone - US

Composition of insulin for nasal administration

Provided is an insulin-containing granulated composition for nasal administration comprising a crystalline cellulose aggregate having a specific particle d...

T Oki，T Hanafusa，S Haruta - US

Chronic obstructive pulmonary disease (COPD), asthma; Aerosol administration a compound that inhibits exocytosis in mucus secreting cells produced by modif...

A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions invol...

CP Quinn，KA Foster，JA Chaddock - US

Therapeutic peptides

A decapeptide of the formula: Ac-A 1 -A 2 -D-Trp-Ser-Tyr-A 3 -A 4 -A 5 -A 6 -A 7 -NH 2 wherein each A 1 and A 2 , independently, is D-Trp, D-β-Nal, or D-p-X-Phe, wherein X is a halogen or CH 3 ; A 3 is D-β-Nal, D-Trp, D-Lys,...

DH Coy，JP Moreau - US

Selective Neurotoxic Lesions of Descending Serotonergic and Noradrenergic Pathways in the Rat

The ability of neurotoxic substances to induce selective lesions of the descending monoaminergic pathways in rats was investigated. Saline, 6-hydroxydopami...

Odd-Geir，Berge，Ole，... - 《Journal of Neurochemistry》

DIETARY SUPPLEMENTS AND METHODS OF PREPARING AND ADMINISTERING DIETARY SUPPLEMENTS

A chewable or non-chewable, palatable and shelf stable dietary supplement for animals including a carrier matrix formed of a natural substance and an effective amount of a medicament intermixed with the carrier matrix. Methods for admini...

MD Finke - WO