Diphosphate Salt of a Derivative of 4 "- 9 - desoxo - 9th - aza - 9th - homoeritromicina and Pharmaceutical composition
申请(专利)号：
PE20000000645
申请日期：
2000-06-27
公开/公告号：
PE02872001A1
公开/公告日期：
2001-03-05
申请(专利权)人：
PFIZER PRODUCTS INC.
摘要：
Refers to two polymorphs diphosphate (2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R) - 5 - [[2 - didesoxi - 3 - methyl - 3 - methyl - 4 - [(propilamino) methyl] - or - L ribo - hexopiranosil] oxy] - 2 - Ethyl - 3 - trihidroxi 3,4,10,5,8,10,12,14 - hexamethyl - 11 - [[3.4.Tridesoxi - 3 - 6 - (dimethylamino) -. Beta. - D - xilo hexopiranosil] oxy] - 1 - 6 - azaciclopentadecan oxa - - 15 - ona formula I; n is 0 - 8); a esmectica Crystalline mesophase Liquid Crystal; (b) a diphosphate CrystallinePresents a model of x-ray Diffraction, is presented in the form of Ribbon exhibits longitudinal Split,A 15% increase in Weight with a loss of birefringence to approximately 87% relative humidity, The Liquid Crystal has 5% to 6% Water; or is laminar or Prismatic,Being highly birefringent; The Compound absorbs Water gradually up to 13% at a relative humidity Of 87%, being deliquescent Salt phosphate at a relative humidity of 90%.The maximum number of water molecules required for the stabilization of the Crystal Lattice is 8. It also relates to a process for Preparation.Compound I can be useful for the treatment of infections
展开
相似文献
参考文献
引证文献
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
