A critical analysis of (trans) dermal delivery of substances encapsulated within liposomes and niosomes is presented. Topical liposomes or niosomes may ser...
topicaltransdermaltransfersomesFor more than two decades, researchers have attempted to find a way to use the skin as a portal of entry for drugs in ...
Historically, the skin was thought to be a simple homogenous barrier. However, it is now known to be a highly specialised organ, and plays a key role in homeostasis. The protective properties of the skin are provided by the outermost lay...
Many currently available drugs show unfavourable physicochemical properties for delivery into or across the skin and temporary chemical modulation of the p...
In its first part, this review paper discusses skin morphology and barrier function of the stratum corneum for drug permeation after its transdermal admini...
A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a pharmaceutically active agent that includes a corresponding steroid and a steroid derivative; and a carrier for th...
Topical drug delivery formulations with optical amounts of vasodilator. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue depositio...
Transdermal drug delivery generated major interest among large pharmaceutical companies in the 1980s and 1990s due to potential advantages of avoidance of first-pass metabolism, avoidance of exposure to the chemical and biological condit...
There is considerable interest in the skin as a site of drug application for both local and systemic effect. However, the skin, in particular the stratum corneum, possesses a formidable barrier to drug penetration thereby limiting topica...
A subset of sensory neurons co-express TRPM8 ion channels and 5-HT1B receptors.TRPM8 and 5-HT1BRs form molecular complexes that also incorporate phospholip...
