Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain
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24
摘要：
Chronic administration of antidepressants produces region-specific adaptive changes in the radioligand binding propertiesofN-methyl-d-aspartate (NMDA) receptors. We hypothesized that this effect of chronic antidepressant administration was owing to an alterationin NMDA receptor subunit composition. This hypothesis was examined usingin situ hybridization with [35S]-labeled riboprobes to quantify the impact of chronic (16 d) injection with either imipramine (15 mg/kg) or citalopram (20mg/kg) on the levels of transcripts encoding NMDA receptor subunits in mouse brain. These antidepressants altered the levelsof mRNA encoding the ζ-subunit in a parallel fashion, with both drugs either reducing transcript levels (e.g., in the cortex,cerebellum, thalamus, and striatum) or producing no substantial effects (e.g., hippocampus). In contrast, these antidepressantsoften produced distinct, region-specific effects on mRNA lev
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DOI：
10.1007/BF02761776
被引量：
年份：
1998
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