C-H bond functionalization via hydride transfer: formation of α-arylated piperidines and 1,2,3,4-tetrahydroisoquinolines via stereoselective intramolecular amination of benzylic C-H bonds.
摘要：
Treatment of aldehydes of type (I), (IV), (VI), and (IX) with Tos-NH2 leads to imines which in the presence of BF3·OEt2 undergo cyclization to -arylated piperidines and tetrahydroisoquinolines.
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关键词：
ring closure reactions pyridine derivatives isoquinoline derivatives fused pyridine derivatives diastereoselective syntheses, enantioselective syntheses (incl. cis/trans-isomerism)
DOI：
10.1002/chin.201251032
被引量：
年份：
2012
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