Increased enantioselectivity in the presence of benzylamine in the heterogeneous hydrogenation of [formula omitted]-unsaturated carboxylic acids
摘要：
The use of one equivalent of benzylamine increased the enantioselectivity in the heterogeneous catalytic hydrogenation of α , β-unsaturated carboxylic acids over cinchonidine-modified 5% Pd/Al 2O 3 catalyst. The beneficial effect of the amine additive was dependent on substrate structure. The highest effect, a more than sixfold increase in the enantiomeric excess, was obtained in the hydrogenation of itaconic acid. This is the first report on the enantioselective hydrogenation of a prochiral α , β-unsaturated dicarboxylic acid over a supported heterogeneous metal catalyst.
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关键词：
Unsaturated carboxylic acid Enantioselective Hydrogenation Heterogeneous Palladium Cinchonidine Itaconic acid
DOI：
10.1016/j.jcat.2005.01.023
被引量：
年份：
2005
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