Antihypercholesterolemic compounds

 - US

HMG-CoA reductase inhibitors

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1

RL Smith，W Halczenko，GD Hartman，... - US

Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors

Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceuti...

JR Regan，KE Neuenschwander - US

Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof

Compounds of the formula ##STR1## wherein one of R and R o is ##STR2## and the other is primary or secondary C 1 -6 alkyl not containing an asymmetric carbon atom, C 3 -6 cycloalkyl or phenyl(CH 2 ) m --, wherein R 4 is hydrogen, C 1...

FG Kathawala - US

Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor compound

A pharmaceutical dosage form comprising an HMG-CoA reductase inhibitor compound, e.g., fluvastatin sodium, is disclosed which is stabilized against pH-related degradation by an alkaline stabilizing medium capable of imparting a pH of at ...

MB Kabadi，RV Vivilecchia - CA

Hypotensive agents

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and the pharmaceutically acceptable salts thereof are produced by couplin...

ML Hoefle，S Klutchko - US

Renin inhibitors containing alpha-heteroatom amino acids

The invention concerns novel renin-inhibitory peptides which contain novel amino acids having an 伪-heteroatom attached to the backbone of the amino acid. ...

JS Kaltenbronn，JT Repine - US

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3- carboxylic acids

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline- 3- carboxylic acids and the pharmaceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4- tetrahydroisoquinoline with a suitably substit...

ML Hoefle，S Klutchko - US

Alkaline stabiling medium

A pharmaceutical dosage form comprising an HMG-CoA reductase inhibitor compound, e.g., fluvastatin sodium, is disclosed which is stabilized against pH-rela...

MB Kabadi，RV Vivilecchia

Mercaptoacyl derivatives of substituted prolines

New mercaptoacyl derivatives of substituted prolines which have the general formula ##STR1## are useful as hypotensive agents.

MA Ondetti，J Krapcho - US