By administering with food; drug is dalcetrapib; use in treatment of cardiovascular disease, coronary heart disease, coronary artery disease

The invention is directed to a method of increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-me...

Y Urata，T Ishikawa - US

Upregulation Of Type Iii Endothelial Cell Nitric Oxide Synthase By Agents That Disrupt Actin Cytoskeletal Organization

A use for agents that disrupt actin cytoskeletal organization is provided. In the instant invention, agents that disrupt actin cytoskeletal organization are found to upregulate endothelial cell Nitric Oxide Synthase activity. As a result...

JK Liao - US

Diabetes-related biomarkers and methods of use thereof

The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.

MS Urdea，MP Mckenna，PA Arensdorf

Diabetes-related biomarkers and methods of use thereof

Diabetes-related biomarkers and methods of use thereof., , The Patent Description & Claims data below is from USPTO Patent Application 20120179484, Diabete...

I Tethys Bioscience

Up-regulation of type III endothelial cell nitric oxide synthase by HMG-CoA reductase inhibitors

(57) to a new use of the [summary] HMG-CoA reductase inhibitor is provided. In the present invention, the HMG-CoA reductase inhibitors, which via a mechanism other than to prevent the formation of oxidized LDL, it up-regulates the activi...

リャオ ジェームズ，ケー.，ラウフス ウルリッヒ，...

PHARMACEUTICAL COMPOSITION CONTAINING STATIN-ENCAPSULATED NANOPARTICLE

The object is to provide a novel nanotechnology-based strategy for a anti-angiogenesis therapy, particularly statin encapsulated in a biodegradable nanopar...

K Egashira

FREE FLOWING, FROZEN COMPOSITIONS COMPRISING A THERAPEUTIC AGENT

Disclosed are frozen, free-flowing compositions that may contain one or more therapeutic agents and at least one flavoring agent, such compositions being useful for the delivery of an effective amount of a therapeutic agent to an individ...

Z Tavakoli，E Ostertag

Pharmaceutical composition comprising a combination of metformin and a statin

A pharmaceutical composition comprising: (i) metformin, optionally in the form of one of its pharmaceutically acceptable salts, (ii) a statin, optionally in the form one of its pharmaceutically acceptable salts, and optionally one or mor...

JL Junien，A Edgar - EP

Useful in treating or preventing conditions such as pulmonary hypertension, ischemic stroke, impotence, heart failure, hypoxia-induced conditions, insulin ...

A use for rho GTPase function inhibitors is provided. In the instant invention, rho GTPase function inhibitors are found to upregulate endothelial cell Nit...

JK Liao - WO

IL1RL-1 as a cardiovascular disease marker and therapeutic target

Methods for evaluating the likelihood that a subject will benefit from treatment with an agent for reducing the risk of a cardiovascular condition, by eval...

RT Lee