LIPOSOMES WITH ENHANCED CIRCULATION TIME
The liposome composition containing a pharmaceutical agent entrapped, characterized by (a) the dimensions of liposomes comprised mainly between about 0.07 and 0.5 microns; (B) at least about 50 mole% of a lipid rigidifying the membrane, ...
ALLEN Theresa M.，GABIZON Alberto - US
Liposomes with enhanced circulation time
A liposome composition which contains between 1-20 mole percent of an amphipathic lipid derivatized with a polyalkylether, as exemplified by phosphatidylethanolamine derivatized with polyethyleneglycol. The derivatized lipid enchances th...
MC Woodle，FJ Martin，A Yau-Young，... - US
5013556 Liposomes with enhanced circulation time: Martin Woodle, Francis Martin, Annie Yau-Young, Carl Redemann assigned to Liposome Technology Inc
A liposome composition which contains between 1-20 mole percent of an amphipathic lipid derivatized with a polyalkylether, as exemplified by phosphatidylethanolamine derivatized with polyethyleneglycol. The derivatized lipid enchances th...
HL Bush，JN Graber，JA Jakubowski，... - 《Biotechnology Advances》
Water insoluble microparticles that have a layer of phospholipid embedding in surface
A microsuspension system and method for its preparation is disclosed. The microsuspension contain lipospheres, which are solid, water-insoluble micropartic...
AJ Domb - US
Method of binding collagen recognizing substances to liposomes
Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target s...
R Margalit - US
Capsule loading technique
Disclosed is a method for loading capsules having a semipermeable membrane with a chemically active substance to be released over time. The method first involves gradually deflating and dehydrating the capsules and subsequently soaking t...
WG Tsang - US
Liposomes
Polyanionic therapeutic compounds, generally nucleic acids, are complexed with calcium phosphate and entrapped within liposomes. For DNA vaccines, the comp...
G Gregoriadis - American Cancer Society
Encapsulation of ionizable agents in liposomes
Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at b...
ANDREW S. JANOFF，PIETER R. CULLIS，MARCEL B. BALLY，...
LIPOSOME EXTRUSION METHOD
A suspension of liposomes, preferably formulated to contain an entrapped drug, whose sizes are predominantly greater than about 1 micron is passed through ...
FJ Martin，JK Morano
Spraying a compressed fluid comprising a water insoluble active material in solvent, into an aqueous solution comprising a surfactant, forming microparticl...
Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepare...
IB Henriksen，AK Mishra，GW Pace，...
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