Methodology for eliciting an analgesic response in a living subject
申请(专利)号：
US08/631434
申请日期：
19960412
公开/公告号：
US05891842A
公开/公告日期：
19990406
申请(专利权)人：
TRUSTEES OF TUFTS COLLEGE
被引量：
摘要：
The present invention provides a method for eliciting an opioidal analgesia in a living subject using two classes of chemical compositions previously thought to have directly contradictory and physiologically antagonistic roles in the spinal analgesic process. The present methodology relies upon a concurrent administration of an opioid in marginal concentrations in combination with marginal doses of substance P or its related entities which function in a synergistic relationship and mechanism of action. The methodology relies upon a powerful potentiation and enhancement of an opioid-mediated response by the enhancing action of substance P to modulate or eliminate pain and other nociceptive responses, as well as inducing anesthesia.
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