A concise enantioselective synthesis of (+)-muscarine from (R)-O-benzylglycidol [(R)-benzyloxymethyloxirane]

A concise enantioselective synthesis of (+)-muscarine has been established via the novel formation of a 3,4-dihydrofuran starting from (R)-O-benzylglycidol.

Seiichi，Takano，Yoshiharu，... - 《Journal of the Chemical Society Chemical Communications》

ChemInform Abstract: A Concise Enantioselective Synthesis of (+)-Muscarine from (R)-O-Benzylglycidol ((R)-Benzyloxymethyloxirane)

ChemInform Abstract: A Concise Enantioselective Synthesis of (+)-Muscarine from (R)-O-Benzylglycidol ((R)-Benzyloxymethyloxirane)...

S Takano，Y Iwabuchi，K Ogasawara - 《Cheminform》

A concise enantioselective synthesis of (+)-muscarine from (R)-O-benzylglycidol [(R)-benzyloxymethyloxirane]

A concise enantioselective synthesis of (+)-muscarine has been established via the novel formation of a 3,4-dihydrofuran starting from (R)-O-benzylglycidol.

Seiichi，Takano，Yoshiharu，... - 《Journal of the Chemical Society》

A concise enantioselective synthesis of (+)-muscarine from (R)-O-benzylglycidol [(R)-benzyloxymethyloxirane]

A concise enantioselective synthesis of (+)-muscarine has been established via the novel formation of a 3,4-dihydrofuran starting from (R)-O-benzylglycidol.

S Takano，Y Iwabuchi，K Ogasawara - 《Journal of the Chemical Society Chemical Communications》

Chiral heteroaryloxymethyloxiranes

Several approaches to the synthesis of chiral heteroaryloxymethyloxiranes have been developed. The most direct method involves the reaction of an aromatic moiety bearing a readily displaceable leaving group with the sodium salt of chiral...

DE Mcclure，EL Engelhardt，K Mensler，... - 《Journal of Organic Chemistry》

The genotoxicity of enantiomeric aliphatic epoxides

The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoa...

JE Sinsheimer，R Chen，SK Das，... - 《Mutation Research/genetic Toxicology》

Preparation of 3-fluoropropane-1,2-diol from glycidol (hydroxymethyloxirane).

Forty plant species were grown in pots containing viruliferous Xiphinema diversicaudatum (Micol.) for 15 wk to assess the host range of the nematode in rel...

RJ Dummel，E Kun - 《Journal of Medicinal Chemistry》

Multilevel Density Functional Theory

We present applications to aqueous solutions of methyloxirane and glycidol.doi:10.1021/acs.jctc.0c00940Gioia MarrazziniTommaso GiovanniniMarco ScavinoFranco EgidiHenrik KochJournal of Chemical Theory and Computation...

G Marrazzini，T Giovannini，M Scavino，... - 《Journal of Chemical Theory & Computation》

Multilevel Density Functional Theory

This results in a reduction of computational cost. We outline the theory and implementation, and discuss applications to aqueous solutions of methyloxirane ...

G Marrazzini，T Giovannini，M Scavino，...

Total synthesis of (±)- and (+)-latifine

Based on the racemic synthesis, (R)-(+)-latifine (R)-(1), the unnatural enantiomer, has also been synthesized from (S) -0-benzylglycidol (S) -(3) via (S)-1 -benzyloxy-3-phenylthio-propan-2-01 (S)-(4) as a key ...

S Takano - 《Journal of the Chemical Society Perkin Transactions》