Synthesis, crystal structures and DNA-binding properties of two new mononuclear copper(II) complexes
摘要：
Two mononuclear copper(II) complexes, [Cu(bpy) 2 (CH 3 OH)](pic) 2 ( 1 ) and [Cu(Me 2 bpy) 2 (H 2 O)](pic) 2 ( 2 ) (bpy=2,2′-bipyridine; Me 2 bpy=4,4′-dimethyl-2,2′-bipyridine; Hpic=2,4,6-trinitrophenol), were synthesized and characterized by elemental analyses, conductivity measurements, IR, UV–Visible spectroscopy and single crystal X-ray analyses. Both complexes 1 and 2 are mononuclear compounds. The copper atom in complex 1 is in a distorted square pyramidal geometry with a CuN 4 O chromophore as revealed from the τ value (0.25), while the Cu(II) ion in complex 2 displays a distorted trigonal bipyramidal stereochemistry with τ=0.72. Hydrogen bonding interactions and π–π stacking interactions link the mononuclear copper complex 1 or 2 into a 1D infinite chain. The interactions of the two mononuclear complexes with herring sperm DNA ( HS -DNA) have been studied by UV–visible absorption titration, fluorescence titration and ethidium bromide (EB) displacement experiments. The results suggest that both complexes might bind to DNA by intercalation.
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DOI：
10.1007/s11243-008-9111-x
被引量：
年份：
2008
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