A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

来自 EBSCO

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作者：

S Miyawaki，Y Nakamura，H Suzuka，M Koba，Y Shibata，R Yasumizu，S Ikehara

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摘要：

We have found a new spontaneous autosomal recessive mutation in mice that causes a systemic absence of lymph nodes and Peyer's patches. The name alymphoplasia, with the gene symbol uly , is proposed for this mutant. The spleen of alylay mice is devoid of well-defined lymphoid follicles, and the thymus does not show a clear cortical-medullary distinction. The mutant homozygotes are deficient in both humoral and cell-mediated immune functions, and are highly susceptible to infections. They have a reduced level of IgM and severely depressed levels of IgG and IgA in their sera, and do not reject allogeneic skin grafts. However, they have mature T and B cells as determined from their cell surface antigens. The results of bone marrow transplantation experiments suggest a mesenchymal disorder as a possible cause of the lack of lymph nodes and of immunodeficiency in the aly mouse. The aly mutant mouse may be a useful animal model of primary immunodeficiency, as are the nu (nude) and scid (severe combined immunodeficiency) mice.

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关键词：

Immunodeficiency Alymphoplasia Animal model Autosomal recessive mutation Mouse

DOI：

10.1002/eji.1830240224

被引量：

880

年份：

1994