Sunazuka T,Omura S. Total synthesis of α-pyrone meroterpenoids,novel bioactive microbial metabolites[J].Chemical Reviews,2005,(12):4559-4580.doi:10.1021/...
Bioactive natural products produced by microbes have almost limitless potential in pharmaceutical applications, and the organic synthesis of such products as lead compounds will result in the creation of new and widely useful pharmaceuti...
Synthetic inhibitors of acetylcholinesterase (AChE) recently have attracted particular attention for treatment of Alzheimer's disease. By systematic screen...
A 20-step total synthesis of (±)-arisugacin A with an overall yield of 2.1% is described here. This synthesis features highly convergent formal [3+3] cycl...
15-Deoxyoxalicine B (1) and decaturins A (2) and B (3) have been isolated from Penicillium decaturense and Penicillium thiersii, two previously undescribed...
In a search for new inhibitors of the IFN-gamma mediated signal transduction in HeLa S3 cells using secreted alkaline phosphatase (SEAP) as reporter gene, ...
An isolated novel polynucleotide comprising a nucleotide sequence encoding at least one polypeptide involved in biosynthesis of pyripyropene A, a recombinant vector comprising the polynucleotide and a transformant comprising the polynucl...
Provided is a method for manufacturing a pyripyropene by culturing a microorganism, created by the introduction of a specific polynucleotide or a recombinant vector comprising same, together with an intermediate compound necessary for th...
