LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimickin...

B Vester，J Wengel - 《Biochemistry》

Progress in Antisense Technology

Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick hybridization. Once bound, the antisense agent either disable...

Crooke，T Stanley - 《Annual Review of Medicine》

LNA (Locked Nucleic Acid):  High-Affinity Targeting of Complementary RNA and DNA

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimickin...

B Vester，J Wengel - 《Biochemistry》

A concise update on the applications of chiral ferrocenyl phosphines in homogeneous catalysis leading to organic synthesis.

Recent advances in the chemistry of all the well-known chiral ferrocynyl phosphines in homogeneous catalysis, with a special thrust to consolidate all the ...

TJ Colacot - 《Chemical Reviews》

LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA.

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimickin...

Vester，Birte，Wengel，... - 《Biochemistry》

Hepatocyte growth factor variants

not available

DK Kirchhofer，MD Peek - US

Building oligonucleotide therapeutics using non-natural chemistries - ScienceDirect

-methyl sense strand and a phosphorothioate antisense strand. The first fully modified aptamer (2′--methyl) was reported in 2005. It is expected that futu...

C Wilson，AD Keefe - 《Current Opinion in Chemical Biology》

Building oligonucleotide therapeutics using non-natural chemistries

Modified nucleotides are increasingly being utilized in all categories of therapeutic oligonucleotides to increase nuclease-resistance, target affinity and specificity. The extent to which these substitutions are tolerated varies with th...

WAD Keefe - 《Current Opinion in Chemical Biology》

Photocleavable biotin phosphoramidite for 5'-end-labeling, affinity purification and phosphorylation of synthetic oligonucleotides.

We report the design, synthesis and evaluation of a non-nucleosidic photocleavable biotin phosphoramidite (PCB-phosphoramidite) which provides a simple met...

O Jerzy，KO Edyta，KJ Rothschild - 《Nucleic Acids Research》

1,1'-Di(heteroatom)-functionalised ferrocenes as [N,N], [O,O] and [S,S] chelate ligands in transition metal chemistry.

Dppf is one of the most useful and popular ligands in coordination chemistry. Its overwhelming success has overshadowed and arguably even delayed the devel...

Ulrich，Siemeling，Tanja-Corinna，... - 《Chemical Society Reviews》