Nucleic acid ligands

A new class of nucleic acid compounds, referred to as nucleic acid antibodies, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligand components of the...

L Gold，C Tuerk - US

High-affinity RNA ligands of basic fibroblast growth factor

Methods are described for the identification and preparation of nucleic acid ligand solutions to basic fibroblast growth factor (bFGF). Included in the invention are nucleic acid ligands to bFGF which are inhibitors of bFGF and 2'-amino-...

N Janjic，L Gold - 《Biotechnology Advances》

Orthopedic lesions in tethered cord syndrome: the importance of early diagnosis and treatment on patient outcome.

Background: 聽 Many of the patients with tethered cord syndrome (TCS) are admitted because of neurological symptoms, while some are admitted because of the...

M Gharedaghi，F Samini，H Mashhadinejad，... - 《Archives of Bone & Joint Surgery》

Flow cell SELEX

Described herein are methods for improved partitioning between high and low affinity nucleic acid ligands identified through the SELEX method, termed Flow Cell SELEX. The Flow Cell SELEX method achieves partitioning between high and low ...

DJ Schneider，R Vanderslice，L Gold - US

STRUCTURE BASED AND COMBINATORIALLY SELECTED OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER TARGETING AP-1 TRANSCRIPTION FACTORS

The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-...

DG Gorenstein，BA Luxon，J Leary - US

Controlled release nanoparticle having bound oligonucleotide for targeted delivery

The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The co...

OC Farokhzad，YJ Sang，RS Langer - US

Filipil compositions and methods for treating cancer

On 27 October 2015 the US Food and Drug Administration announced that it had approved Imlygic (talimogene laherparepvec), an oncolytic virus, for the treatment of melanoma that cannot be removed by surgery. The genetically modified live ...

Steven Libutti，M Kwon，A Tandle

Treatment of Liver Cancer

In patients without cirrhosis, the diagnosis of hepatocellular carcinoma (HCC) requires a biopsy and is routinely done by a pathologist with an expertise i...

TF Greten

Point-of-care immunoassay for quantitative small analyte detection

Point-of-care immunoassay for quantitative small analyte detection.The Patent Description & Claims data below is from USPTO Patent Application 20130102003,...

L Decimadx

Compositions and methods of developing oligonucleotides and oligonucleotide analogs having antiviral activity

Methods of identifying and preparing anti-infectious agent compounds comprising the steps of incubating single stranded nucleic acids or nucleic acid analo...

W Pan，JF Wang