Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study.
摘要：
Membranous epithelial or "M" cells in lymphoid follicle epithelium of Peyer's patches extend between the adjacent columnar cells, forming a separating lymphocytes in the epithelial cell layer from the intestinal lumen. They lack developed microvilli, , or terminal web but contain numerous vesicles. of particles from ligated intestinal loops by such cells without evidence of further uptake of these particles by lymphocytes has been described by others. (), an enzyme known to function orally and parenterally as a foreign protein antigen, was injected into the unligated intestines of fasted healthy 2-month-old white Swiss to determine if would be absorbed in detectable quantities by M cells, and whether subsequent uptake of by lymphocytes could be documented. At intervals from 1 to 60 min the most distal ileal Peyer's patch was fixed, removed, reacted with -3,3'-diaminobenzidine and examined by light and electron microscopy for reaction product. At 1 min adhered to surfaces of columnar cells and M cells and extended down into surface pits in the M cell. After 5 min was found in vesicles of M cells but not in columnar cells. At 1 hr was detected in the between M cells and their enfolded lymphocytes, as well as in vesicles within these lymphocytes. of intestinal material by M cells with subsequent uptake by lymphocytes provides a specific route for antigen uptake into the intestinal lymphoid system.
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关键词：
Animals Animals, Newborn Mice Epithelium Lymphoid Tissue Peyer' s Patches Intestinal Mucosa Epithelial Cells Macromolecular Substances
被引量：
年份：
1977
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