Signaling Pathways that Regulate Cell Division
摘要：
Cell division requires careful orchestration of three major events: entry into mitosis, chromosomal segregation, and cytokinesis. Signaling within and between the molecules that control these events allows for their coordination via checkpoints, a specific class of signaling pathways that ensure the dependency of cell-cycle events on the successful completion of preceding events. Multiple positive- and negative-feedback loops ensure that a cell is fully committed to division and that the events occur in the proper order. Unlike other signaling pathways, which integrate external inputs to decide whether to execute a given process, signaling at cell division is largely dedicated to completing a decision made in G1 phase-to initiate and complete a round of mitotic cell division. Instead of deciding if the events of cell division will take place, these signaling pathways entrain these events to the activation of the cell-cycle kinase cyclin-dependent kinase 1 (CDK1) and provide the opportunity for checkpoint proteins to arrest cell division if things go wrong.
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关键词：
CDC2 Protein Kinase Cell Cycle Proteins Signal Transduction Cell Division DNA Replication Feedback, Physiological Models, Biological DNA Damage Cell Cycle Checkpoints
DOI：
10.1101/cshperspect.a005942
被引量：
年份：
2012
万方医学
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