Design, Synthesis, and Characterization of Photolabeling Probes for the Study of the Mechanisms of the Antiviral Effects of Ribavirin
摘要：
Ribavirin, the only small molecule available so far for treating hepatitis-C-virus infection, was recently used in an emergency context to treat patients with severe acute respiratory syndrome (SARS) in the early stages of the disease. To study the mechanisms responsible for the antiviral effects of ribavirin by using a photolabeling approach, we designed, synthesized, and characterized the azidotriazole nucleosides 1 and 2 as photolabeling probes of ribavirin. These probes were synthesized either by performing nucleophilic substitution of the corresponding bromotriazole nucleoside with NaN 3 ( Scheme2 ) or by directly coupling the azidotriazole with the protected ribose sugar ( Scheme4 ). The azidotriazole nucleosides 1 and 2 showed a fast, clear-cut photochemical reaction, which suggests that they are promising candidates for use in photolabeling studies.
展开
DOI：
10.1002/hlca.200490079
被引量：
年份：
2004
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
