Magnesium and zinc-catalyzed thioketalization

Reaction of a variety of ketones with ethane-1,2-dithiol to form thioketals proceeds very efficiently and under mild conditions using magnesium or zinc triflates as catalyst.

EJ Corey，K Shimoji - 《Tetrahedron Letters》

A new general synthetic route to bridged carboxylic ortho esters

Acylation of the readily available 3-methyl-3-hydroxymethyl oxetane () leads to the corresponding oxetane esters () which rearrange smoothly in the presenc...

EJ Corey，N Raju - 《Cheminform》

Chiral Reagents from Tartaric Acid—1‐Benzyloxy‐3,4‐epoxy‐2‐butanol, a Versatile Intermediate for the Synthesis of Enantiomers

Publication » Chiral Reagents from Tartaric Acid?1Benzyloxy3,4-epoxy-2-butanol, a Versatile Intermediate for the Synthesis of Enantiomers.

DCE Hungerbühler，D Seebach，DSND Wasmuth - 《Angewandte Chemie International Edition》

Aminopyridines as acylation catalysts for tertiary alcohols

The acylation of unreactive alcohols with acid anhydrides is greatly facilitated by the addition of a catalytic (0.02鈥 0.1 equivalent) amount of a 4-dialkylaminopyridine. The reaction is faster in nonpolar than in polar solvents and acet...

A Hassner，LR Krepski，V Alexanian - 《Tetrahedron》

Reactions of .alpha.,.beta.-epoxysilanes with organocuprate reagents. New stereospecific olefin synthesis

α,β-Epoxysilanes react with organocuprate reagents in a regio- and stereospecific manner to give good yields of β-hydroxyalkylsilanes, which can be stereospecifically converted to olefins in high yield under mild conditions.

PF Hudrlik，D Peterson，RJ Rona - 《Journal of Organic Chemistry》

Conversion of ketones having δ, -π-functions to cyclopentanols by zinc-trimethylchlorosilane

A new method for five-membered ring annulation is described which involves free radical generation from ketones by zinc-trimethylchlorosilane followed by internal addition to a π-bond.

E.J. Corey，Stephen G. Pyne - 《Tetrahedron Letters》

ChemInform Abstract: CONVERSION OF KETONES HAVING Δ,.vepsiln±PI.‐FUNCTIONS TO CYCLOPENTANOLS BY ZINC‐TRIMETHYLCHLOROSILANE

Aus dem 3-ButenyI-cyclohexanon (I) erhlt man mit Zink und Trimethylsilylchlorid die Cyclisierungsprodukte (I I)-(IV).

COREY, E. J.，PYNE, S. G. - 《Chemischer Informationsdienst》

Total synthesis of 12-( [formula omitted])-10-hydroxy- [formula omitted]-11,12-epoxyeicosa-5,9,14-( [formula omitted])-trienoic acids, metabolites of arachidonic acid in mammalian blood platelets

The two isomeric hydroxy-11,12-epoxides produced from arachidonic acid in mammalian blood platelets have been identified by comparison with totally synthetic substances as the C(10)-diastereomers of

EJ Corey，J Kang，BC Laguzza，... - 《Tetrahedron Letters》

ChemInform Abstract: STUDIES ON THE CONFORMATIONAL MOBILITY OF ARACHIDONIC ACID. FACILE MACROLACTONIZATION OF 20-HYDROXYARACHIDONIC ACID

20-Hydroxyarachidonic acid is converted to the corresponding 21-membered lactone via the 2-thiolpyridine ester in > 90% yield and at a rate which is approx...

EJ Corey，S Iguchi，JO Albright，... - 《Tetrahedron Letters》

Synthesis of a new series of potent inhibitors of thromboxane A2 biosynthesis

The pyridino prostanoids 9, 12 and 14 have been synthesized (in racemic form) and have been found to be effective inhibitors of the biosynthesis of thrombo...

EJ Corey，SG Pyne，AI Schafer - 《Tetrahedron Letters》